Lucinda H. Elliott
Office Location: FSC153
Phone Number: 717-477-1504
B.S. Zoology/Biology, Marshall University,
Ph.D. Immunology and Microbiology,
University of Kentucky School of Medicine
After spending over 25years in clinical research studying the mechanisms
involved in the immuosuppressive effects of brain tumors (glioblastoma
multiforme), which are the most common malignant brain tumors in adults, I discovered
my real passion was teaching. I accepted
a position at Shippensburg University in 1998 and currently teach immunology,
virology and cell biology. I also helped
develop the biotechnology concentration and the course, techniques in biotechnology,
which I c--teach with Dr. William Patrie.
I was also instrumental in developing the pre-forensics option linked to
the biotechnology concentration and establishing the affiliation with the
Cumberland County Forensic Laboratory.
In 2005 I completed a sabbatical at the United States Army Research
Institute for Infectious Diseases (USAMRIID) in the laboratory of Dr. Robert
Ulrich, where I developed my current research focus on autophagy and the role
this process plays in cancer biology and the immune system. In my spare time, I enjoy going to the gym
and visiting my grandchildren in Kentucky, where I hope to retire on my farm in
the near future.
Autophagy, which literally means ”self-eating”, is a normal homeostatic process
used by all eukaryotic cells to remove protein aggregates and old organelles by
wrapping them in double membrane vesicles (autophagosomes) for degradation and
recycling by lysosomes. Autophagy is
also induced by stressors such as nutrient starvation or infections, where it
functions as a mechanism to target intracellular pathogens for
destruction. The autophagy pathway is
also an alternative pathway of programmed cell death if it is not regulated. Autophagy has been demonstrated to play
important roles in development, neurodegenerative diseases, aging, cancer and
the immune system. My lab is focused on
the role of autophagy in growth of glioblastoma cancer cells and clearance of
the intracellular pathogen, Shigella
Immunology, Microbiology, Cell Biology, Techniques in Biotechnology, Human Biology
and the honor seminar; Viruses and History.
Undergraduate Student Research Projects 2012
Grega, Beth Ann, Christine Gonzalez and Jonathan Wagner. Engineering of
dsRed/LC3 Expression Vector to Visualize Autophagy in Cloned Cell Lines
Okwaare, Winnie, Kyle Chelius, Abigail Kraus and John Pilato. Over Expressing Atg5 in Glioma Cells to
Determine the Role of Atg5 in Survival and Clearance of Intracellular Shigella flexneri
Lee, Shannon, Luke Perry and
Chris Batties. Identification of
Bacterial Isolates Using rRNA Gene Sequence Analysis (in collaboration with Dr.
Shadle, Erik, Joseph Sergent,
Carley Heck, Jessica Rauchut.
Expression, Cloning and Sequencing of Atg4c Variant 1 and p62 Auotphagy
Related cDNA from Glioma Cells. (in collaboration with Dr. Sherri Bergsten)
MS Student Research
Makul, Alma, 2008, Elucidating the Role of Atg5 Protein in
Autophagy and Apoptosis in SNB19 Glioma Cells
Fedrow, Alison, 2004, Prevalence of Several Tick-Borne
Pathogens in Central Pennsyvania.
Richardson, Jenny, 2002, Isolating and Sequencing Human
Calpastatin from a Human Liver cDNA Library
Elliott, L.H., L.A. Morford, W.H.
Brooks and T.L Roszman. Primary malignant brain tumors: Immune defects and
immune evasion. In J. Finke & R. Bukowski (ed). Cancer immunotherapy at the
crossroads: How tumors evade immunity and what can be done. Humana Press 2004
Mayo, K. Miller,K., Hkami, R.,
Ulrich, R. and Elliott, L.H. Expression of autophagy related genes in human
CD14 monocytes infected with Streptococcus
pyogenes, GeneBank, (Accession Number EU283339), 2007
Burdge, D.R., Patrie, W.J., and
Elliott, L.H. Expression of autophagy related genes in SNB19 glioma cells.
GeneBank, (Accession Number EU283338), 2007