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Department of Biology
142 Franklin Science Center
Shippensburg University
1871 Old Main Drive
Shippensburg, PA 17257-2299
717-477-1401
biology@ship.edu

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/uploadedImages/Ship/Biology/Dr_Elliott.jpgLucinda H. Elliott

Professor

Office Location: FSC153

Phone Number: 717-477-1504

Email: lhelli@ship.edu

 

Education

B.S. Zoology/Biology, Marshall University, Huntington WV
Ph.D. Immunology and Microbiology, University of Kentucky School of Medicine

Profile

After spending over 25years in clinical research studying the mechanisms involved in the immuosuppressive effects of brain tumors (glioblastoma multiforme), which are the most common malignant brain tumors in adults, I discovered my real passion was teaching.  I accepted a position at Shippensburg University in 1998 and currently teach immunology, virology and cell biology.  I also helped develop the biotechnology concentration and the course, techniques in biotechnology, which I c--teach with Dr. William Patrie.  I was also instrumental in developing the pre-forensics option linked to the biotechnology concentration and establishing the affiliation with the Cumberland County Forensic Laboratory.  In 2005 I completed a sabbatical at the United States Army Research Institute for Infectious Diseases (USAMRIID) in the laboratory of Dr. Robert Ulrich, where I developed my current research focus on autophagy and the role this process plays in cancer biology and the immune system.  In my spare time, I enjoy going to the gym and visiting my grandchildren in Kentucky, where I hope to retire on my farm in the near future.

Research Interests

Autophagy, which literally means ”self-eating”, is a normal homeostatic process used by all eukaryotic cells to remove protein aggregates and old organelles by wrapping them in double membrane vesicles (autophagosomes) for degradation and recycling by lysosomes.  Autophagy is also induced by stressors such as nutrient starvation or infections, where it functions as a mechanism to target intracellular pathogens for destruction.  The autophagy pathway is also an alternative pathway of programmed cell death if it is not regulated.  Autophagy has been demonstrated to play important roles in development, neurodegenerative diseases, aging, cancer and the immune system.  My lab is focused on the role of autophagy in growth of glioblastoma cancer cells and clearance of the intracellular pathogen, Shigella flexneri.

Courses Taught

Immunology, Microbiology, Cell Biology, Techniques in Biotechnology, Human Biology and the honor seminar; Viruses and History.

Undergraduate Student Research Projects 2012

Grega, Beth Ann, Christine Gonzalez and Jonathan Wagner. Engineering of dsRed/LC3 Expression Vector to Visualize Autophagy in Cloned Cell Lines

Okwaare, Winnie, Kyle Chelius, Abigail Kraus and John Pilato.  Over Expressing Atg5 in Glioma Cells to Determine the Role of Atg5 in Survival and Clearance of Intracellular Shigella flexneri 

Lee, Shannon, Luke Perry and Chris Batties.  Identification of Bacterial Isolates Using rRNA Gene Sequence Analysis (in collaboration with Dr. William Patrie)

Shadle, Erik, Joseph Sergent, Carley Heck, Jessica Rauchut.  Expression, Cloning and Sequencing of Atg4c Variant 1 and p62 Auotphagy Related cDNA from Glioma Cells. (in collaboration with Dr. Sherri Bergsten)

MS Student Research Projects 

Makul, Alma, 2008, Elucidating the Role of Atg5 Protein in Autophagy and Apoptosis in SNB19 Glioma Cells

Fedrow, Alison, 2004, Prevalence of Several Tick-Borne Pathogens in Central Pennsyvania.

Richardson, Jenny, 2002, Isolating and Sequencing Human Calpastatin from a Human Liver cDNA Library

Selected Publications

Elliott, L.H., L.A. Morford, W.H. Brooks and T.L Roszman. Primary malignant brain tumors: Immune defects and immune evasion. In J. Finke & R. Bukowski (ed). Cancer immunotherapy at the crossroads: How tumors evade immunity and what can be done. Humana Press 2004

Mayo, K. Miller,K., Hkami, R., Ulrich, R. and Elliott, L.H. Expression of autophagy related genes in human CD14 monocytes infected with Streptococcus pyogenes, GeneBank, (Accession Number EU283339), 2007

Burdge, D.R., Patrie, W.J., and Elliott, L.H. Expression of autophagy related genes in SNB19 glioma cells. GeneBank, (Accession Number EU283338), 2007