2021 Football
denotes a Pennsylvania State Athletic Conference Eastern Division contest.
| Saturday, September 4th | |
West Virginia State @ Shippensburg | 1:00pm | View Game |
| Saturday, September 25th | |
Bloomsburg @ Shippensburg | 1:00pm | View Game |
| Saturday, October 9th | |
West Chester @ Shippensburg | 1:00pm | View Game |
| Saturday, October 23rd | |
Millersville @ Shippensburg Homecoming | 1:00pm | View Game |
| Saturday, November 6th | |
Lock Haven @ Shippensburg University | 1:00pm | View Game |
| Saturday, November 13th | |
Mercyhurst @ Shippensburg University | 1:00pm | View Game |